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An alkaloid with diverse biological activities; an agonist of TRPV1 (EC50 = 28.2 nM for inducing calcium uptake in CHO cells expressing human TRPV1); shortens the action potential duration in isolated canine Purkinje fibers at 10 µM; increases the latency to paw withdrawal in the hot plate test in rats at 0.68 mmol/animal; topical application reduces croton oil-induced EAr edema in mice; induces emesis in musk shrews; decreases disease severity in a guinea pig model of HSV-2-induced genital herpes
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